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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB1
All Species:
17.58
Human Site:
S381
Identified Species:
32.22
UniProt:
P08183
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08183
NP_000918.2
1280
141479
S381
S
I
D
S
Y
S
K
S
G
H
K
P
D
N
I
Chimpanzee
Pan troglodytes
XP_519183
1280
141455
S381
S
I
D
S
Y
S
K
S
G
H
K
P
D
N
I
Rhesus Macaque
Macaca mulatta
NP_001028059
1283
141504
S384
S
I
D
S
Y
S
K
S
G
H
K
P
D
N
I
Dog
Lupus familis
XP_539461
1269
140189
T375
A
I
D
N
F
S
T
T
G
Y
K
P
E
C
I
Cat
Felis silvestris
Mouse
Mus musculus
P21447
1276
140628
S377
S
I
D
S
F
S
K
S
G
H
K
P
D
N
I
Rat
Rattus norvegicus
P43245
1277
141369
K380
S
I
D
S
F
S
T
K
G
H
K
P
D
S
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508941
1368
147746
R475
Q
I
D
S
F
S
E
R
G
D
K
P
G
N
L
Chicken
Gallus gallus
XP_418636
1307
144961
A412
Q
I
D
S
S
S
N
A
G
Y
K
L
D
H
V
Frog
Xenopus laevis
NP_001081394
1287
141487
E391
K
I
D
S
F
S
K
E
G
L
K
P
D
K
I
Zebra Danio
Brachydanio rerio
XP_001922717
1340
147081
E427
P
I
D
S
S
S
K
E
G
H
K
P
D
R
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
D393
K
I
D
P
L
S
T
D
G
K
L
L
N
Y
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
A405
V
I
D
S
S
S
K
A
G
R
K
D
M
K
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O80725
1286
139009
N373
N
I
D
S
Y
S
T
N
G
K
V
L
D
D
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96
55.7
N.A.
87.1
80.6
N.A.
62.1
69.6
67.6
56
N.A.
41.1
N.A.
44.5
N.A.
Protein Similarity:
100
99.8
97.7
75.4
N.A.
93.3
90.1
N.A.
76.6
83.6
81.8
73.5
N.A.
60.4
N.A.
62.6
N.A.
P-Site Identity:
100
100
100
46.6
N.A.
93.3
73.3
N.A.
53.3
46.6
66.6
66.6
N.A.
26.6
N.A.
53.3
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
100
86.6
N.A.
73.3
73.3
73.3
73.3
N.A.
33.3
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
16
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
100
0
0
0
0
8
0
8
0
8
70
8
0
% D
% Glu:
0
0
0
0
0
0
8
16
0
0
0
0
8
0
0
% E
% Phe:
0
0
0
0
39
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
100
0
0
0
8
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
47
0
0
0
8
0
% H
% Ile:
0
100
0
0
0
0
0
0
0
0
0
0
0
0
70
% I
% Lys:
16
0
0
0
0
0
54
8
0
16
85
0
0
16
0
% K
% Leu:
0
0
0
0
8
0
0
0
0
8
8
24
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
8
0
0
8
0
0
8
8
0
0
0
0
8
39
0
% N
% Pro:
8
0
0
8
0
0
0
0
0
0
0
70
0
0
0
% P
% Gln:
16
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
8
0
8
0
0
0
8
0
% R
% Ser:
39
0
0
85
24
100
0
31
0
0
0
0
0
8
0
% S
% Thr:
0
0
0
0
0
0
31
8
0
0
0
0
0
0
0
% T
% Val:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
31
0
0
0
0
16
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _